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The diagnosis can be confirmed by estimating the G6Pd activity of the red cell but this may not be entirely accurate if there is considerable reticulocytosis. A number of screening rests are usually present: haemoglobinaemia, methaemalbuminaemia, baemoglobinuria, ahaptoglobinaemia and later
haemosiderinuria.
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This is by removal of the toxic agent. Recovery is usually rapid but if the anemia is severe, transfusion of red cells with a normal enzyme complement may be required. Thereafter, the patient should be advised to avoid drugs, which may precipitate the disorder. Splenectomy is without value.
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